Table 2.
Anthropometric characteristics and levels of biochemical and instrumental parameters of subjects with JIA who underwent treatment with MTX and Biologic drugs and healthy controls
| Parameters | JIA MTX Group A (n = 22) |
JIA Biologic Group B (n = 27) | Controls (n = 49) | p-valuea,b,c |
|---|---|---|---|---|
| Anthropometric parameters | ||||
| Sex (male/female) | 2/20 | 7/20 | 24/25 | |
| Age (years) | 9.4 ± 3.2 | 11.1 ± 4.2 | 11.3 ± 3.4 | 0.12 |
| Age at onset (years) | 5.0 ± 2.5 | 4.6 ± 3.5 | – | 0.67 |
| Age at start of therapy (years) | 5.9 ± 2.9 | 7.6 ± 3.9 | – | 0.09 |
| Duration of disease (years) | 4.4 ± 3.2 | 6.5 ± 3.2 | – | 0.03 |
| JADAS 27 | 0.5 (0.5–1.9) | 0.5 (0.5–2.0) | – | 0.53 |
| Active/inactive disease | 7/15 | 12/15 | – | 0.40 |
| Weight (kg) | 34.7 ± 14.9 | 38.4 ± 16.7 | 42.9 ± 17.3 | 0.14 |
| Weight SDS | 0.15 ± 0.96 | − 0.41 ± 1.33 | − 0.06 ± 1.07 | 0.20 |
| Height (cm) | 134.3 ± 18.4 | 143.3 ± 24.3 | 144.5 ± 20.6 | 0.16 |
| Height SDS | − 0.07 ± 1.17 | 0.02 ± 1.31 | − 0.22 ± 1.27 | 0.71 |
| BMI (kg/m2) | 18.4 ± 3.4 | 17.8 ± 3.4 | 19.6 ± 3.7 | 0.08 |
| BMI SDS | 0.16 ± 0.97 | − 1.13 ± 3.22 | 0.17 ± 1.06 | 0.01c |
| Laboratory parameters | ||||
| Creatinine (mg/dl) | 0.5 ± 0.1 | 0.5 ± 0.2 | 0.6 ± 0.2 | < 0.001 b,c |
| eGFR (ml/min/1.73 m2) | 99.0 ± 8.7 | 99.3 ± 12.0 | 122.5 ± 19.8 | < 0.001b,c |
| Cystatin C (mg/dl) | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 | < 0.001b,c |
| BUN (mg/dl) | 12.8 ± 2.5 | 13.7 ± 3.1 | 11.7 ± 1.4 | 0.002c |
| UAE |
1.1 (1.05–1.57) |
1.1 (1.05–1.09) |
1.0 (1.01–1.06) |
0.007b |
| ERS (mm/h) |
7.5 (4.8–13.2) |
14.0 (9.0–21.0) |
1.0 (1.00–1.00) |
< 0.001a,c |
| CRP (mg/dl) |
0.2 (0.20–0.23) |
0.4 (0.2–1.5) |
0.2 (0.2–0.2) |
< 0.001a,b,c |
| US parameters | ||||
| Right RRI | 0.7 ± 0.04 | 0.7 ± 0.1 | 0.6 ± 0.04 | < 0.001b,c |
| Left RRI | 0.7 ± 0.03 | 0.7 ± 0.1 | 0.6 ± 0.04 | < 0.05a,b,c |
| Mean RI | 0.7 ± 0.04 | 0.7 ± 0.1 | 0.6 ± 0.04 | < 0.001b,c |
| Right length | 9.1 ± 0.8 | 12.2 ± 14.6 | 8.3 ± 0.8 | 0.1 |
| Left length | 9.2 ± 0.8 | 12.3 ± 14.6 | 8.3 ± 0.8 | < 0.001b,c |
| Right width | 1.4 ± 0.3 | 1.6 ± 0.4 | 1.8 ± 0.4 | 0.09 |
| Left width | 1.4 ± 0.2 | 1.5 ± 0.4 | 1.8 ± 0.4 | < 0.001b,c |
Data are mean ± standard deviations
SDS-Weight—standard deviation score-weight; SDS-Height—standard deviation score-height; BMI—body mass index; SDS-BMI—standard deviation score-body mass index; F—female; M—male; e-GFR—estimated glomerular filtration rate; UAE—urinary albumin excretion; RRI—renal resistive index; BUN—blood urea nitrogen; ESR—erythrocyte sedimentation rate; CRP—C-reactive protein
aJIA MTX vs. JIA Biologic, bJIA MTX vs. Controls, cJIA Biologic vs. Controls