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. 2023 Jun 21;9:48. doi: 10.1038/s41526-023-00286-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Hypergravity exposure to 20 × g significantly delayed fibroblast migration compared to 1 × g controls (P = 0.033, n = 10). Simulated microgravity intermitted with 15 × g (P = 0.016, n = 11) and 20 × g (P = 0.007, n = 4) hypergravity also reduced fibroblast migration. The gravity-induced effects were not significant in fibroblasts exposed to cortisol except for the 15 × g T group (P = 0.0468, n = 5). smg = simulated microgravity. 15 × g T and 20 × g T are hypergravity transition groups. Error bars show standard deviations. *P < 0.05, **P < 0.005. Statistical tests included ANOVA followed by post hoc analysis (see “Statistical analyses“). Asterisks without line show significance level compared to 1 × g control. Measures are divided by mean value of 1 × g controls to obtain relative values.