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. 2023 Jun 8;14:1185744. doi: 10.3389/fphys.2023.1185744

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Copyright © 2023 Pan, Karey, Nieves-Cintron, Chen, Hwang, Hammock, Pinkerton and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dark-light difference (subtracting measures in the light cycle from those in dark 2 cycle) over the 16 weeks of study. SHS-exposed group had significantly greater diurnal variation in activity level (A) than the FA-exposed group, an effect that persisted 4 weeks after the cessation of SHS exposure. FA- and SHS-exposed mice had similar diurnal variation in MBP (B) and HR (C). Significant main effects from two-way repeated ANOVA are indicated with “+”. *p < 0.05, FA vs. SHS. Numbers in parentheses indicate sample sizes.