Table 2.
Criteria and cut-off points to diagnose sarcopenia in individuals with IPF in the different studies.
| Criteria | Main criteria definition | Lean muscle mass | Muscle function | References | ||||
|---|---|---|---|---|---|---|---|---|
| Handgrip strength | Gait speed | SPPB | TUG | FTSST | ||||
| EWGSOP2 | Low muscle strength + low muscle mass; severity of sarcopenia involve low physical performance | ASMI: Male < 7.0 kg·m−2 Female < 5.5 kg·m−2 |
Male < 27 kg Female < 16 kg | ≤ 0.8 m·s−1 | ≤ 8 | ≥20 s | (5) | |
| AWGS 2019 | Low ASM + low muscle strength/low physical performance; severe sarcopenia: low ASM + low muscle strength + low physical performance | ASM: DXA (M: < 7.0 kg·m−2, Female < 5.4 kg·m−2) BIA (M: < 7.0 kg·m−2, Female < 5.7 kg·m−2) |
Male < 28 kg Female < 18 kg | < 1 m·s−1 (6MWT) | ≤ 9 | ≥12 s | (7, 8) | |
| The lowest quartile of T4MI (Q4) | Patients' T4MI ranged from minimum to 25% | (9) | ||||||
| The lowest quartile of PMcas (Q4) | Patients' PMcas ranged from minimum to 25% | (6) | ||||||
SPPB, Short Physical Performance Battery; TUG, timed up and go test; FTSST, Five Times Sit-to-Stand Test; EWGSOP2, European Working Group on Sarcopenia in Older People 2019; ASMI, appendicular skeletal muscle mass index; AWGS 2019, Asian Working Group on Sarcopenia in 2019; ASM, Appendicular skeletal muscle mass; DXA, Dual-energy X-ray absorptiometry; BIA, Bioelectrical impedance analysis; 6MWT, 6-min walk test; T4MI, the muscle index at T4; PMcas, cross-sectional area of the pectoralis muscles.