Table 2.
The miRNA signature involved in significant KEGG pathways.
| KEGG pathway | miRNAs | Target genes | p-value |
|---|---|---|---|
| Proteoglycans in cancer | 20 | 112 | 1.211E−16 |
| Adherens junction | 20 | 49 | 2.932E−12 |
| Viral carcinogenesis | 20 | 104 | 7.936E−09 |
| Hepatitis B | 19 | 78 | 2.281E−07 |
| Protein processing in endoplasmic reticulum | 21 | 95 | 8.18E−07 |
| TGF-beta signaling pathway | 17 | 47 | 9.288E−07 |
| Pancreatic cancer | 19 | 42 | 9.288E−07 |
| Bacterial invasion of epithelial cells | 20 | 48 | 9.288E−07 |
| Hippo signaling pathway | 21 | 72 | 1.983E−06 |
| Cell cycle | 21 | 70 | 4.562E−06 |
| Colorectal cancer | 20 | 41 | 6.81E−06 |
| Prostate cancer | 21 | 56 | 1.037E−05 |
| Estrogen signaling pathway | 20 | 55 | 1.306E−05 |
| Acute myeloid leukemia | 17 | 38 | 1.677E−05 |
| Glycosaminoglycan biosynthesis - keratan sulfate | 12 | 10 | 2.874E−05 |
| Pathways in cancer | 21 | 184 | 3.088E−05 |
| Focal adhesion | 21 | 108 | 3.515E−05 |
| Fatty acid biosynthesis | 9 | 5 | 4.006E−05 |
| Oocyte meiosis | 17 | 59 | 4.028E−05 |
| Glioma | 19 | 37 | 4.028E−05 |
| Endocytosis | 21 | 100 | 4.028E−05 |
| p53 signaling pathway | 19 | 43 | 6.164E−05 |
| N-Glycan biosynthesis | 14 | 27 | 6.176E−05 |
| Renal cell carcinoma | 20 | 43 | 7.457E−05 |
| Neurotrophin signaling pathway | 21 | 67 | 7.712E−05 |
| Chronic myeloid leukemia | 18 | 45 | 7.842E−05 |
| Shigellosis | 20 | 39 | 8.722E−05 |
| Prolactin signaling pathway | 18 | 42 | 0.0001111 |
| Non-small cell lung cancer | 17 | 33 | 0.0001449 |
| mTOR signaling pathway | 18 | 38 | 0.000156 |
| FoxO signaling pathway | 20 | 72 | 0.0001875 |
| Lysine degradation | 17 | 25 | 0.0001893 |
| Small cell lung cancer | 19 | 49 | 0.0003562 |
| Sphingolipid signaling pathway | 19 | 60 | 0.0003722 |
| Ubiquitin mediated proteolysis | 19 | 74 | 0.0003919 |
| Endometrial cancer | 19 | 32 | 0.0004231 |
| Insulin signaling pathway | 21 | 74 | 0.0004354 |
| AMPK signaling pathway | 20 | 67 | 0.0004477 |
| ErbB signaling pathway | 21 | 49 | 0.0004477 |
| HIF-1 signaling pathway | 20 | 58 | 0.0006434 |
| Thyroid cancer | 17 | 19 | 0.0007077 |
| Signaling pathways regulating pluripotency of stem cells | 20 | 72 | 0.0007951 |