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. 2023 Jun 13;9(6):e17224. doi: 10.1016/j.heliyon.2023.e17224

Fig. 5.

Fig. 5

Construction and validation of FAM-related risk score for ccRCC in TCGA and ICGC cohorts. (A) Univariate Cox regression analysis of DEGs identifying OS-related FAMGs. (B) Partial likelihood deviance of LASSO coefficient profiles. (C) Multivariate Cox regression analysis for nine selected FAMGs of the risk score. (D) The mRNA expression levels of the nine selected FAMGs by RT–qPCR. ROC curve of the FAM-related risk score in the ICGC cohort. (E) Kaplan–Meier curves of the FAM-related risk score in TCGA cohort. (F) Kaplan–Meier curves of the FAM-related risk score in the ICGC cohort. Abbreviations: ccRCC, clear cell renal cell carcinoma; DEGs, differentially expressed genes; FAM, fatty acid metabolism; FAMGs, fatty acid metabolism genes; ICGC, International Cancer Genome Consortium; LASSO, least absolute shrinkage and selection operator; ROC, receiver operating characteristic; RT–qPCR, real-time quantitative PCR; TCGA, The Cancer Genome Atlas.