Table 1.
Reaction step | k+ | k- | |
---|---|---|---|
E + S ⇄ ES | k1, k-1 | 2 × 106 M−1 s−1 | 0.075 s−1 |
ES ➝ EP | k2, k-2 | 7.5 s−1 | 0 |
E + P ⇄ EP | k3, k-3 | 2 × 106 M−1 s−1 | 0.040 s−1 |
EP ➝ EQ | k4, k-4 | 3.5 s−1 | 0 |
E + Q ⇄ EQ | k5, k-5 | 2 × 106 M−1 s−1 | 0.082 s−1 |
EQ ➝ ER | k6, k-6 | 2.5 s−1 | 0 |
E + R ⇄ ER | k7, k-7 | 2 × 106 M−1 s−1 | 2.0 s−1 |
E: P450 51A1, S: dihydrolanosterol, P: 14α-CH2OH dihydrolanosterol, Q: 14α-CHO dihydrolanosterol, R: dihydro FF-MAS.