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. 2023 Jun 8;14:1197894. doi: 10.3389/fimmu.2023.1197894

Figure 3.

Figure 3

Platelets from ZIP1/3 DKO mice are hyperresponsive towards GPCR agonists, but not to ITAM-coupled receptor agonists in aggregometry. Platelet aggregation was measured using Fibrintimer 4-channel aggregometer after stimulation of washed platelets isolated from WT and ZIP1/3 DKO mice with (A) different GPCR agonists (thrombin, ADP, U46619) and (B) ITAM-coupled receptor agonists (collagen, CRP) using the indicated concentrations; n=5-15 (two-way ANOVA + Bonferroni), *P<0.05, **P<0.01,***P<0.001.