Table 2.
MR sensitivity analyses of AS and BMD at different sites and in different age groups.
| Exposure | Outcome | No.of Ivs |
Heterogeneity tests | Directional horizontal pleiotropy test | ||
|---|---|---|---|---|---|---|
| Methods | Cochran’sQ (P) | MR-Egger intercept (P) | Ppleiotropy* | |||
| AS | TB-BMD | 25 | MR Egger | 22.02(0.52) | 3.89E-03(0.10) | 0.468 |
| IVW | 25.01(0.41) | |||||
| AS | FN-BMD | 23 | MR Egger | 29.48 (0.10) | 5.01E-03(0.17) | 0.114 |
| IVW | 32.25(0.07) | |||||
| AS | LS-BMD | 23 | MR Egger | 19.76(0.54) | 4.67E-04(0.90) | 0.666 |
| IVW | 19.78(0.60) | |||||
| AS | FA-BMD | 25 | MR Egger | 18.16(0.75) | 7.22E-03(0.25) | 0.757 |
| IVW | 19.58(0.72) | |||||
| AS | Heel-BMD | 25 | MR Egger | 66.88(3.66e-06) | -1.80E-03(0.29) | 0.001 |
| IVW | 70.35(1.93e-06) | |||||
| AS | 15 or less | 25 | MR Egger | 31.73 (0.11) | 7.34E-03(0.22) | 0.110 |
| IVW | 33.92(0.09) | |||||
| AS | 15-30 | 25 | MR Egger | 33.24(0.08) | 2.27E-02(0.06) | 0.055 |
| IVW | 39.08(0.027) | |||||
| AS | 30-45 | 25 | MR Egger | 32.69(0.09) | 1.29E-02(0.08) | 0.059 |
| IVW | 37.38(0.04) | |||||
| AS | 45-60 | 25 | MR Egger | 16.94(0.81) | -3.11E-03(0.47) | 0.844 |
| IVW | 17.47(0.83) | |||||
| AS | 60 or more | 25 | MR Egger | 28.03(0.21) | -6.65E-04(0.88) | 0.300 |
| IVW | 28.06(0.26) | |||||
| TB-BMD | AS | 8 | MR Egger | 5.17(0.52) | 4.27E-03(0.29) | 0.155 |
| IVW | 6.49(0.48) | |||||
| LS-BMD | AS | 5 | MR Egger | 4.47(0.21) | 1.98E-02(0.44) | 0.333 |
| IVW | 5.65(0.22) | |||||
| Heel-BMD | AS | 17 | MR Egger | 26.12(0.04) | -5.89E-04(0.88) | 0.049 |
| IVW | 26.17(0.05) | |||||
* detected by MR-PRESSO Global Test.