TABLE 3.
Comparison of infants exposed and not exposed to drugs containing parabens.
| Study population | |||
|---|---|---|---|
| Exposed n = 1,124 | Not exposed n = 191 | p-value | |
| Birth weight (g), mean (±SD) | 1,158.1 (±342.7) | 963.0 (±414.3) | <0.0001 a |
| Gestational age (weeks), mean (±SD) | 28.7 (±2.0) | 27.1 (±2.5) | <0.0001 a |
| 24–25 | 95 (57.6) | 70 (42.4) | |
| 26–27 | 219 (84.2) | 41 (15.8) | |
| 28–31 | 810 (91.0) | 80 (9.0) | |
| Sex, n (%) | |||
| Male | 559 (82.9) | 115 (17.1) | 0.003 a |
| Female | 564 (88.7) | 72 (11.3) | |
| Not determined at birth | 1 (20.0) | 4 (80.0) | |
| Year of admission, n (%) | |||
| 2017 | 200 (87.7) | 28 (12.3) | 0.01 b |
| 2018 | 251 (85.7) | 42 (14.3) | |
| 2019 | 216 (88.5) | 28 (11.5) | |
| 2020 | 232 (88.5) | 30 (11.5) | |
| 2021 | 225 (78.1) | 63 (21.9) | |
| Length of stay (days), median [min–max] | 48 [1–199] | 7 [1–150] | <0.0001 a |
| Mortality, n (%) | 23 (17.0) | 112 (83.0) | <0.0001 a |
a
χ2 test or Student’s t-test
b
Cochran–Armitage test for trend.