TABLE 4.

Exposure to drugs containing parabens (PB) according to the gestational age.

		Gestational age (weeks of gestation)
	Exposed infant n = 1,124	(24–25) n = 95	(26–27) n = 219	(28–31) n = 810
Daily PB intake, mg/kg/d
Mean (±SD)	2.2 (1.4)	2.7 (1.2)	2.6 (1.4)	2.1 (1.4)
Median [p25%–p75%]	2.1 [1.0–3.1]	2.8 [1.8–3.8]	2.6 [1.6–3.3]	1.9 [0.9–2.9]
Min–max	0.1–11.1	0.1–5.2	0.2–11.1	0.2–10.8
Duration of PB exposure, days
Mean (±SD)	33.1 (22.3)	50.4 (32.8)	45.3 (24.5)	27.8 (17.3)
Median [p25%–p75%]	30.0 [17.0–45.5]	53.0 [22.0–73.0]	47.0 [28.0–59.0]	27.0 [14.0–38.0]
Min–max	1.0–142.0	1.0–129.0	1.0–142.0	1.0–94.0
Cumulative PB intake, mg/kg
Mean (±SD)	80.3 (84.6)	136.1 (104.3)	123.5 (103.1)	62.0 (67.8)
Median [p25%–p75%]	52.5 [20.5–116.0]	120.2 [52.7–212.7]	107.6 [50.1–167.5]	41.6 [17.4; 82.5]
Min–max	0.1–872.2	0.1–394.8	0.3–872.2	0.2–592.2
PB intake > 10 mg/k/d, n (%)	39 (3.5)	2 (2.1)	9 (4.1)	28 (3.5)
Duration of PB intake > 10 mg/k/d, days
Mean (±SD)	6.3 (9.2)	1.5 (0.7)	9.2 (17.0)	5.8 (5.3)
Median [p25%–p75%]	3.0 [2.0–7.0]	1.5 [1.0–2.0]	2.0 [1.0–5.0]	3.5 [2.5–7.5]
Min–max	1.0–53.0	1.0–2.0	1.0–53.0	1.0–23.0
DOL at the first exposure
Median [min–max]	14 [1–183]	25 [6–162]	18 [4–183]	13 [1–135]
DOL 1–7, n (%)	117 (10.3)	2	9	108
DOL 8–14, n (%)	455 (40.4)	17	68	372
DOL 15–21, n (%)	270 (23.9)	27	56	189
DOL 22–28, n (%)	82 (7.2)	12	21	51
DOL >28, n (%)	205 (18.1)	42	70	95
DOL at the last exposure
Median [min–max]	53 [5–199]	105 [14–180]	75 [13–199]	46 [5–159]
DOL 1–7, n (%)	3 (0.2)	1	1	3
DOL 8–14, n (%)	33 (2.8)	2	3	30
DOL 15–21, n (%)	76 (6.7)	3	3	72
DOL 22–28, n (%)	74 (6.5)	3	2	71
DOL >28, n (%)	943 (83.8)	91	215	639

DOL, day of life; PBs, parabens.