Table 1.
Acr homologs identified by structural similarity search
| No. | Acr/Accession | PDB | Z | RMSD | PDB description |
|---|---|---|---|---|---|
| 1 | AcrIB/ACV38859.1 | 5fvj-A | 17.3 | 2.3 | Acetyltransferase TacT |
| 2 | AcrVA5/WP_046699157.1 | 5c82-A | 11.2 | 1.7 | Nourseothricin acetyltransferase |
| 3 | AcrIF11/OHU91773.1 | 6gw6-A | 6.3 | 3.2 | RES toxin |
| 4 | AcrIF11/MBO08902.1 | 6d0h-A | 5.8 | 2.8 | ParT, COG5654 (RES domain) |
| 5 | AcrIF11/BAG80428.1 | 2q5t-A | 6.4 | 3.1 | Cholix toxin |
| 6 | AcrIF11/KHN50706.1 | 4ow6-B | 5.7 | 3.4 | Diphtheria toxin |
| 7 | AcrVIA6/ETD74580.1 | 4pu4-D | 5.3 | 2.3 | Antitoxin HipB |
| 8 | AcrIIA1/MCN72780.1 | 4yg1-A | 5.3 | 2.3 | Antitoxin HipB |
| 9 | AcrIIA1/KTA35071.1 | 6cf1-B | 5.7 | 3.8 | Antitoxin HigA |
| 10 | AcrIIA1/OPX53912.1 | 3vwb-A | 6.3 | 3.3 | VirB |
| 11 | AcrIIA1/OEH82315.1 | 2grm-A | 7.3 | 3.9 | PrgX |
| 12 | AcrIF9/PMT73868.1 | 5i8j-A | 5.7 | 2.9 | Dmd |
| 13 | AcrIIC3/CWS40682.1 | 5zyf-A | 6.9 | 2.7 | Cas2, CRISPR-Cas protein involved in adaptation step |
| 14 | AcrIA/AAR27922.1 | 5ean-A | 13.1 | 2.4 | Dna2 |
| 15 | AcrIA/AAR27922.1 | 7lw7-A | 12.7 | 3.0 | Exonuclease V |
| 16 | AcrIA/AAR27922.1 | 3h4r-A | 11.3 | 3.2 | Exodeoxyribonuclease 8 |
| 17 | AcrIIA21/WP_000384271.1 | 3k2z-B | 8.5 | 1.7 | LexA |
| 18 | AcrIIA21/WP_000384271.1 | 4pt7-B | 15 | 1.5 | RepA |
| 19 | AcrIIA11/WP_118225168.1 | 3nct-D | 6.4 | 2.8 | PsiB, negative regulator of RecA |
| 20 | AcrIIA11/WP_118225168.1 | 5oqm-D | 6.7 | 4.4 | CTD of Mediator of RNA polymerase II transcription subunit |
| 21 | AcrIC7/EWC40192.1 | 1ghh-A | 7.5 | 2.3 | DNA-damage-inducible protein I (DinI) |
| 22 | AcrIIA8/WP_038352084.1 | 2kz4-A | 10.2 | 1.3 | Putative head-tail adaptor |
| 23 | AcrIIA8/WP_035290260.1 | 6te9-E | 10.1 | 2.5 | Adaptor protein RCC01688 |
| 24 | AcrIIA8/WP_084113462.1 | 3f3b-A | 8.7 | 1.8 | Phage-like element PBSX protein xkdH |
| 25 | AcrIIA8/WP_066523678.1 | 2pp6-A | 8.3 | 1.7 | ATP-binding sugar transporter-like protein |
| 26 | AcrIIA8/WP_002597422.1 | 6zlv-A | 7.5 | 2.0 | Rod shape-determining protein MreC |
| 27 | AcrVA3/STZ14554.1 | 1u3e-M | 6.6 | 2.5 | HNH endonuclease DNA binding domain |
CTD, C-terminal domain; PDB, Protein Data Bank; RMSD, root mean squared deviation between Cα atoms coordinates of aligned query and target structures; Z, DALI Z-score.