Table 2.

Recommendations on possible targets for future studies to increase evidence for the management of neonatal hypoglycemia.

• Prospective, preferably multicenter randomized controlled trials evaluating long-term outcome until at least mid-childhood with power to detect even small reductions in neurodevelopmental outcomes depending on: o different risk factors (between risk factors and within a specific risk factor group) o different operational thresholds (overtreatment vs. undertreatment) o duration and frequency of hypoglycemia o different preventive and treatment methods (e.g. guidelines) o early identification of inborn endocrine or metabolic disease causing severe neonatal hypoglycemia o symptomatic/asymptomatic hypoglycemia o the influence of alternative cerebral energy fuels (e.g. ketones, lactate) • Prospective cohort studies evaluating the individual risk for severe hypoglycemia according to different risk factors and development of risk factor specific screening and treatment approaches • Randomized controlled trials of signs of hypoglycemia: Does training of parents, midwives, and nurses affect early detection of severe hypoglycemia?