TABLE 2.
List of 40 deleterious nsSNPs and the potential formation of a new network of collisions or contacts caused by the substituted amino acids at the relevant sites, as predicted by Chimera 1.16.
| Substitution | New contacts | Amino acids with which pseudobonds formed |
|---|---|---|
| E75K | 5 | No |
| K93N | No | No |
| P105L | 14 | No |
| P105R | 34 | D143, R142, Q141 |
| R117H | 9 | No |
| T131M | 7 | F127 and I133 |
| F135S | 1 | No |
| G152R | 41 | I63, N59 and Q60 |
| S155L | 8 | E183 and S156 |
| R159H | 6 | No |
| G162E | 0 | No |
| H182L | 3 | No |
| H182R | 13 | No |
| L188P | 9 | L184 and M185 |
| E193K | 16 | S234 |
| R196W | 16 | N225 and E193 |
| D198E | 1 | No |
| D198N | 1 | No |
| D198Y | 5 | No |
| R199Q | 15 | H194 and R196 |
| R199W | 13 | R196 |
| D200N | 1 | No |
| D200Y | 10 | No |
| R204C | 2 | No |
| E209K | 0 | No |
| I210F | 13 | No |
| Y230C | 1 | No |
| H237Y | 26 | D231 |
| Y238C | 1 | No |
| Y238S | 1 | No |
| R246C | 0 | No |
| P249R | 32 | T252, P253and I251 |
| P249L | 12 | R240 and I251 |
| Q263R | 12 | S233 |
| G262S | 9 | G239, Y238 |
| R264Q | 0 | No |
| L267P | 2 | No |
| R274W | 33 | T228 and L227 |
| L278P | 7 | R274 |
| C281W | 34 | L276 and C132 |