Table 2.
Baseline cognitive scores and MRI brain volumes for the full sample and by secondary progressive and primary progressive multiple sclerosis subtypes.
| Full sample (n = 114) | SPMS (n = 80, 70.2%) | PPMS (n = 34, 29.8%) | p-value | |
|---|---|---|---|---|
| SDMT Z-score (mean, sd) | −1.11 (1.52) | −1.14 (1.56) | −1.05 (1.46) | 0.77 |
| CVLT T-score (mean, sd) | 53.75 (11.92) | 53.96 (10.57) | 53.24 (14.81) | 0.80 |
| BVMT-R T-score (median, IQR)a,b | 44 (34–56) | 44 (32.75–56.25) | 45 (36–52) | 0.78 |
| Proportion with at least 1 impaired cognitive testc | 48.2% (55) | 48.8% (39) | 47.0% (16) | >0.99 |
| WBV (mL): mean (sd) | 1053.39 (123.58) | 1046.51 (128.52) | 1069.58 (111.20) | 0.34 |
| Total gray matter vol (mL): mean (sd) | 465.92 (58.49) | 463.39 (62.74) | 471.88 (47.30) | 0.43 |
| Deep gray matter vol (mL): mean (sd) | 47.33 (5.05) | 47.03 (5.38) | 48.05 (4.15) | 0.28 |
| Total white matter vol (mL): mean (sd) | 441.29 (73.97) | 437.48 (78.70) | 450.26 (61.56) | 0.36 |
| Mean cortical thickness (mm): mean (sd) | 2.34 (0.21) | 2.35 (0.22) | 2.31 (0.17) | 0.40 |
BVMT-R sample size was n = 113 (80 SPMS, 33 PPMS).
Mann–Whitney U-test was used for tests of the median due to the assignment of 19 for two participants getting BVMT-R scores at the lower bound of the standardization algorithm, giving them each a T-score of <20 rather than an exact T-score.
Impaired defined as more than 1.5 sd below the standardized population mean.
BVMT-R, Brief Visuospatial Memory Test-Revised; CVLT, California Verbal Learning Test, second edition; IQR, interquartile range; mL, milliliter; mm, millimeter; PPMS, primary progressive multiple sclerosis; SPMS, secondary progressive multiple sclerosis; sd, standard deviation; SDMT, Symbol Digit Modalities Test; Vol, volume; WBV, whole brain volume.