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. 2023 May 16;7(4):100179. doi: 10.1016/j.rpth.2023.100179

Figure 2.

Figure 2

The role of thrombin and antithrombin in hemostasis, and the mechanism of action of fitusiran. EPCR, endothelial cell protein C receptor; FII, factor II; FIIa, activated factor II; FV, factor V; FVa, activated factor V; FVII, factor VII; FVIIa, activated factor VII; FVIII, factor VIII; FVIIIa, activated factor VIII; FIX, factor IX; FIXa, activated factor IX; FX, factor X; FXa, activated factor X; FXI, factor XI; FXIa, activated factor XI; FXIII, factor XIII; FXIIIa, activated factor XIII; Protein Ca, activated protein C; TAFI, thrombin activatable fibrinolysis inhibitor; TF, tissue factor; TM, thrombomodulin.