Table 1.
Demographics, vascular risk factors and imaging measures and their correlation to pulse wave velocity (24-h measurement).
| All patients (N = 84) | Pulse wave velocity 24 h (Spearman correlation, rs) |
p | |
|---|---|---|---|
| Demographics | |||
| Age, years, median (IQR) | 72 (14.3) | 0.942 | <0.001 |
| Women, n (%) | 43 (51.2) | −0.024 | 0.831 |
| Education, years, median (IQR) | 10 (3.0) | −0.178 | 0.106 |
| Risk factors | |||
| Hypertension, n (%) | 61 (72.6) | 0.393 | <0.001 |
| Diabetes mellitus, n (%) | 11 (13.1) | −0.006 | 0.958 |
| Smoking, n (%) | 42 (50.0) | 0.036 | 0.751 |
| Cardiac disease, n (%) | 25 (29.8) | 0.282 | 0.009 |
| Systolic blood pressure, mmHg, mean ± SD | 122.7 ± 9.8 | 0.293 | 0.007 |
| Systolic blood pressure variability, mmHg, mean ± SD | 15.8 ± 3.5 | 0.274 | 0.012 |
| MRI parameters (cm3) | |||
| White matter hyperintensity volume, median (IQR) | 5.2 (8.0) | 0.472 | <0.001 |
| Peak width of skeletonized mean diffusivity mmHg, mean ± SD | 3.1 × 10–4 ± 0.4 × 10–4 | 0.452 | <0.001 |
| Total brain volume, median (IQR) | 1091.2 (156.8) | −0.617 | <0.001 |
| Basal ganglia volume, median (IQR) | 530.0 (69.6) | −0.593 | <0.001 |
| Neocortical volume, median (IQR) | 428.9 (55.0) | −0.553 | <0.001 |
| White matter volume, median (IQR) | 557.8 (74.0) | −0.503 | <0.001 |
| Cognitive testing (Z scores) | |||
| Executive function, median (IQR) | 0.219 (0.85) | −0.303 | 0.007 |
| Visuopractical skills, median (IQR) | 0.133 (1.19) | −0.564 | <0.001 |
| Memory and learning, mean ± SD | 0.027 ± 0.92 | −0.397 | <0.001 |
| Global cognitive performance, mean ± SD | 0.025 ± 0.92 | −0.491 | <0.001 |
IQR, interquartile range; MRI, magnetic resonance imaging; SD, standard deviation.