MIC of compounds 24b and 24c against NDM, VIM and IMP expressing bacteria.
| MBL-producing bacteria | Minimum inhibitory concentration (mg L−1)a | |||
|---|---|---|---|---|
| Meropenem | 24b | Meropenem | 24c | |
| E. coli NDM-4 | 0.06 | 8 | 0.25 | 8 |
| E. coli IMP-1 | 0.03 | 8 | 0.5 | 8 |
| E. coli IMP-8 | 0.125 | 8 | 0.25 | 8 |
| Enterobacter cloacae NDM-1 | 0.25 | 8 | 0.25 | 8 |
| E. cloacae VIM-1 | 0.5 | 8 | 0.25 | 8 |
All assays were conducted in triplicate p < 0.001.