Table 1 |.
Demographic and clinical characteristics in 2 independent kidney transplant cohorts
| Characteristics | GoCAR (n = 404) | AUSCADa (n = 212) | P valueb |
|---|---|---|---|
| Recipient age, yr | 49.38 ± 13.52 | 48.44 ± 12.11 | 0.381 |
| Recipient sex | 0.282 | ||
| Female | 129 (31.93) | 77 (36.32) | |
| Male | 275 (68.07) | 135 (63.68) | |
| Recipient race | 1.7e–19 | ||
| Caucasian | 261 (64.6) | 177 (83.49) | |
| Asian | 24 (5.94) | 27 (12.74) | |
| African American | 76 (18.81) | 0 (0) | |
| Hispanic | 25 (6.19) | 0 (0) | |
| Other | 18 (4.46) | 8 (3.77) | |
| Dialysis | 6.0e–04 | ||
| No | 89 (22.03) | 23 (10.95) | |
| Yes | 315 (77.97) | 187 (89.05) | |
| Kidney disease | 1.3e–05 | ||
| Diabetes mellitus | 139 (34.41) | 79 (37.98) | |
| Glomerulonephritis | 74 (18.32) | 66 (31.73) | |
| Hypertension | 77 (19.06) | 14 (6.73) | |
| Polycystic kidney disease | 41 (10.15) | 20 (9.62) | |
| Other | 73 (18.07) | 29 (13.94) | |
| Donor age, yr | 42.02 ± 15.51 | 45.43 ± 16.8 | 0.019 |
| Donor sex | 0.609 | ||
| Female | 197 (48.76) | 105 (50.97) | |
| Male | 207 (51.24) | 101 (49.03) | |
| Deceased donor | 6.5e-10 | ||
| No | 187 (46.29) | 45 (21.23) | |
| Yes | 217 (53.71) | 167 (78.77) | |
| CIT, min | 530.65 ± 494.21 | 501.06 ± 245.1 | 0.324 |
| HLA mismatch | 0.010 | ||
| 0 | 46 (11.39) | 12 (6.19) | |
| 1–2 | 55 (13.61) | 42 (21.65) | |
| 3–4 | 150 (37.13) | 58 (29.9) | |
| 5–6 | 153 (37.87) | 82 (42.27) | |
| Delayed graft function | 9.0e–04 | ||
| No | 334 (82.67) | 150 (70.75) | |
| Yes | 70 (17.33) | 62 (29.25) | |
| Induction type | 5.1e–46 | ||
| Lymphocyte nondepletion | 157 (38.86) | 199 (93.87) | |
| Lymphocyte depletion | 159 (39.36) | 13 (6.13) | |
| None | 88 (21.78) | 0 (0) | |
| Follow-up, d | 1776.98 ± 660.2 | 1637.39 ± 849.81 | 0.038 |
| Death-censored graft loss | 0.002 | ||
| No | 355 (87.87) | 202 (95.28) | |
| Yes | 49 (12.13) | 10 (4.72) |
AUSCAD, Australian Chronic Allograft Dysfunction; CIT, cold ischemia time; GoCAR, Genomics of Chronic Allograft Rejection; HLA, human leukocyte antigen.
a
Several variables in the AUSCAD cohort had missing values: donor age (n = 24), CIT (n = 8), dialysis (n = 2), kidney disease (n = 4), donor sex (n = 6), HLA mismatch (n = 18).
b
P values were calculated using Fisher’s exact test (categorical variables) or Student’s t test (continuous variables).
Values are median ± SD or n (%).