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. Author manuscript; available in PMC: 2023 Jun 22.
Published in final edited form as: Ocul Surf. 2022 Jun 30;25:142–153. doi: 10.1016/j.jtos.2022.06.007

Fig. 2.

Fig. 2.

(1) An increase in SP levels is observed in severe cases of herpes simplex keratitis due to excessive release by damaged nerves. (2) In HSV-1 infected corneas, non-immune cells (CD45−) exhibit reduced cell surface expression of NK1R post-infection and immune cells (CD45+ T-cells and macrophages) show an increase in the NK1R expression. (3) There is also a concurrent SP mediated increase in levels of pro-inflammatory cytokines (IL-6 and IFN-γ).