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(1) SP promotes corneal would healing by inducing IL-8 production in corneal epithelial cells and (2) promoting keratocyte migration. (3) SP promotes fibrotic changes in the cornea through NK1R mediated activation of the RhoA/ROCK pathway which causes (4) myofibroblast differentiation and (5) an increase in the production of collagen I, III, and V, lumican, α-Sooth Muscle Actin (SMA), fibronectin, and increases corneal fibroblasts contraction.
