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. 2023 Jun 7;8(24):21736–21744. doi: 10.1021/acsomega.3c01283

Table 3. 5-HT_1AR GTPγS and 5-HT_7AR Gs cAMP Functional Assay for Agonist Effects.

compound	5-HT_1AR [³⁵S]GTPγS assay			5-HT_7AR adenylate cyclase
compound	EC₅₀ (nM) ± SEM	n	% max ± SEM	EC₅₀ (nM) ± SEM	n	% max ± SEM
5-HT	2.60 ± 0.56	8	101.2 ± 1.1	5.3 ± 1.6	3	95.8 ± 1.6
SYA0340	2.66 ± 0.57	7	101.5 ± 2.8	>10 μM	N/A^a	N/A^a
SYA0340-P1	1.12 ± 0.41	3	94.6 ± 3.1	>10 μM	N/A^a	N/A^a
SYA0340-P2	2.21 ± 0.59	3	96.8 ± 5.1	>10 μM	N/A^a	N/A^a

^a

N/A = not applicable.