Table 4. 5-HT_7AR Gs cAMP Functional Assay Antagonist Effects of SYA0340, SYA0340-P1, and SYA0340-P2.

compound	5-HT1AR [35S]GTPγS assay			5-HT7AR adenylate cyclase
	EC50 (nM) ± SEM	n	% max ± SEM	IC50 (nM) ± SEM	n	% max inhib. ± SEM
SYA0340	agonist		N/Aa	89 ± 14	4	94.7 ± 4.1
SYA0340-P1	agonist		N/Aa	32.1 ± 9.2	3	93.5 ± 4.3
SYA0340-P2	agonist		N/Aa	277 ± 46	4	94.3 ± 3.7
lurasidone	ND		NDa	22.5 ± 2.2	5	98.0 ± 2.0

^aND = not determined; N/A = not applicable.