Table 4.
The top 20 genes from module 1 of (common genes of Alzheimer’s disease and COVID-19 tissues and blood) protein–protein interaction network analyzed using four different topological analysis methods such as MCC, Closeness, Betweenness, and Degree through CytoHubba plugin.
| S. No | Betweenness | Closeness | Degree | MCC |
|---|---|---|---|---|
| 1. | ACTB | ACTB | ACTB | PSMA1 |
| 2. | CDC42 | CDC42 | CDC42 | PSMD2 |
| 3. | RUNX2 | HSPA8 | RUNX2 | PSMC1 |
| 4. | HSPA8 | RUNX2 | GFAP | PSME3 |
| 5. | GFAP | CAV1 | HSPA8 | PSMB3 |
| 6. | ITGA2B | GFAP | CAV1 | ACTB |
| 7. | CAV1 | MAPK8 | GNB1 | RUNX2 |
| 8. | SNRNP70 | PTGS2 | PSMD2 | POSTN |
| 9. | RBX1 | VAMP2 | MAPK8 | ELN |
| 10. | GNB1 | PRKCZ | ITGA2B | SPARC |
| 11. | VAMP2 | PIK3CG | PSMA1 | ACAN |
| 12. | PIK3CG | ITGA2B | PTGS2 | SPRED1 |
| 13. | MAPK8 | WNT4 | ACAN | TP73 |
| 14. | FKBP1A | RBX1 | PSME3 | TIMP3 |
| 15. | MYL6B | ACAN | RBX1 | OAZ1 |
| 16. | PSMD2 | PGR | TRPV1 | MAPK6 |
| 17. | SLC12A1 | PSMD2 | PSMB3 | GFAP |
| 18. | ABCC8 | GNB1 | PSMC1 | CDC42 |
| 19. | OAZ1 | TRPV1 | KCNA1 | HSPA8 |
| 20. | HMBS | MAP2K3 | VAMP2 | SDC4 |