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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Prostate Cancer Prostatic Dis. 2022 Dec 23;26(1):194–200. doi: 10.1038/s41391-022-00636-0

Figure 3:

Figure 3:

Associations between functional HRR deficiency scores and maximum PSA50 response.

LOH 0.75: Loss of heterozygosity (LOH) score, measuring the degree of LOH based on discontinuous SNP typing. LOH events larger than 75% of the respective chromosome arm length are excluded from the score analysis.

LOH-score: Number of LOH events assessed using the scarHRD tool. This score represents number of LOH regions exceeding 15 Mb that do not cover the whole chromosome.

TAI-score: Telomeric allelic imbalance (TAI) reflects the number of sub-chromosomal regions with allelic imbalance extending to the telomere.

LST-score: Number of large-scale state transitions (LST) assessed using the scarHRD tool. The LST score represents the number of chromosomal breaks between adjacent regions of at least 10 Mb length, with a distance between events not more than 3Mb.

HRD-score: Defined as sum of the burden of LOH-Scar, LST-Scar and TAI-scar (LOH-Scar score+ TAI-Scar score +LST-scar)