Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 21;15:45. doi: 10.1186/s13073-023-01193-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Expression patterns of GPR68 and GRID2 across cell types in human dorsal root ganglia (DRG) [35]. The y-axis represents counts per million (CPM) (top) and log(CPM) (bottom) of the pseudo-bulk expression of genes in the annotated cell types in the human DRG from n = 5 donors. DRG neurons are designated in green whereas non-neuronal cells are shown in orange. DRG neurons are molecularly classified into different groups: heavily myelinated limb proprioceptors and A-fiber low-threshold mechanoreceptors (LTMRs) that process innocuous touch sensation and proprioception; C-fiber non-peptidergic (NP) nociceptors that process nociception and pruritus; non-myelinated C-fiber and lightly myelinated A-fiber peptidergic (PEP) nociceptors which process inflammatory heat-induced and sharp pinprick nociception; cold thermoreceptors which are A-fiber and C-fiber nociceptors that process cold sensation