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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1986 Jan;49(1):1–10. doi: 10.1136/jnnp.49.1.1

Arteriovenous malformations of the brain: natural history in unoperated patients.

P M Crawford, C R West, D W Chadwick, M D Shaw
PMCID: PMC1028639  PMID: 3958721

Abstract

Two-hundred and seventeen patients from a total population of 343 patients with arteriovenous malformations, were managed without surgery. Follow up was for a mean of 10.4 years. Using life survival analyses, there was a 42% risk of haemorrhage, 29% risk of death, 18% risk of epilepsy and a 27% risk of having a neurological handicap by 20 years after diagnosis in unoperated patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abad J. M., Alvarez F., Manrique M., Garcia-Blazquez M. Cerebral arteriovenous malformations. Comparative results of surgical vs conservative treatment in 112 cases. J Neurosurg Sci. 1983 Jul-Sep;27(3):203–210. [PubMed] [Google Scholar]
  2. Alvord E. C., Jr, Loeser J. D., Bailey W. L., Copass M. K. Subarachnoid hemorrhage due to ruptured aneurysms. A simple method of estimating prognosis. Arch Neurol. 1972 Oct;27(4):273–284. doi: 10.1001/archneur.1972.00490160001001. [DOI] [PubMed] [Google Scholar]
  3. Forster D. M., Steiner L., Håkanson S. Arteriovenous malformations of the brain. A long-term clinical study. J Neurosurg. 1972 Nov;37(5):562–570. doi: 10.3171/jns.1972.37.5.0562. [DOI] [PubMed] [Google Scholar]
  4. Fults D., Kelly D. L., Jr Natural history of arteriovenous malformations of the brain: a clinical study. Neurosurgery. 1984 Nov;15(5):658–662. doi: 10.1227/00006123-198411000-00003. [DOI] [PubMed] [Google Scholar]
  5. Graf C. J., Perret G. E., Torner J. C. Bleeding from cerebral arteriovenous malformations as part of their natural history. J Neurosurg. 1983 Mar;58(3):331–337. doi: 10.3171/jns.1983.58.3.0331. [DOI] [PubMed] [Google Scholar]
  6. Guidetti B., Delitala A. Intracranial arteriovenous malformations. Conservative and surgical treatment. J Neurosurg. 1980 Aug;53(2):149–152. doi: 10.3171/jns.1980.53.2.0149. [DOI] [PubMed] [Google Scholar]
  7. Jennett B., Bond M. Assessment of outcome after severe brain damage. Lancet. 1975 Mar 1;1(7905):480–484. doi: 10.1016/s0140-6736(75)92830-5. [DOI] [PubMed] [Google Scholar]
  8. Moody R. A., Poppen J. L. Arteriovenous malformations. J Neurosurg. 1970 May;32(5):503–511. doi: 10.3171/jns.1970.32.5.0503. [DOI] [PubMed] [Google Scholar]
  9. Parkinson D., Bachers G. Arteriovenous malformations. Summary of 100 consecutive supratentorial cases. J Neurosurg. 1980 Sep;53(3):285–299. doi: 10.3171/jns.1980.53.3.0285. [DOI] [PubMed] [Google Scholar]
  10. Perret G., Nishioka H. Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section VI. Arteriovenous malformations. An analysis of 545 cases of cranio-cerebral arteriovenous malformations and fistulae reported to the cooperative study. J Neurosurg. 1966 Oct;25(4):467–490. doi: 10.3171/jns.1966.25.4.0467. [DOI] [PubMed] [Google Scholar]
  11. Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. TONNIS W., SCHIEFER W., WALTER W. Signs and symptoms of supratentorial arteriovenous aneurysms. J Neurosurg. 1958 Sep;15(5):471–480. doi: 10.3171/jns.1958.15.5.0471. [DOI] [PubMed] [Google Scholar]
  13. Troupp H., Marttila I., Halonen V. Arteriovenous malformations of the brain. Prognosis without operation. Acta Neurochir (Wien) 1970;22(2):125–128. doi: 10.1007/BF01401164. [DOI] [PubMed] [Google Scholar]
  14. Winn H. R., Richardson A. E., Jane J. A. The long-term prognosis in untreated cerebral aneurysms: I. The incidence of late hemorrhage in cerebral aneurysm: a 10-year evaluation of 364 patients. Ann Neurol. 1977 Apr;1(4):358–370. doi: 10.1002/ana.410010407. [DOI] [PubMed] [Google Scholar]

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