Fig. 1.

OLT1177 improves motor performance after MPTP-acute administration in mice. a Time to fall on the accelerating rotarod device 3 days after MPTP administration. Mice received OLT1177 either at 60 mg/kg (OLT 60) or 200 mg/kg (OLT 200) daily starting one hour before MPTP administration. Saline was used as vehicle. Sham mice that did not receive MPTP were used as control. b The running pattern of the mice at the different speeds on the accelerating rotarod device. Data are pooled from 3 separate experiments and are represented as the mean ± SEM for a and the mean for b. N = 9 for Sham + Saline, N = 12 for MPTP + Saline, N = 9 for MPTP + OLT 60, and N = 14 for MPTP + OLT 200. One-way ANOVA with Tukey’s post hoc correction was used to analyze differences between groups for a with *p < 0.05, **p < 0.01, and ***p < 0.001. Kaplan–Meier test was used to analyze differences between groups for b with ****p < 0.0001 for MPTP + OLT 200 against MPTP + Saline