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. 2023 Jun 21;27:245. doi: 10.1186/s13054-023-04533-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Distribution of estimated individual treatment effects and conditional average treatment effects within each quintile of estimated individual treatment effects. Shown are A the distribution of estimated individual treatment effects of PMX-HA on 28-day survival and B the conditional average treatment effects of PMX-HA within each quintile of estimated individual treatment effects. Higher treatment effects on 28-day survival are equivalent to higher absolute risk reduction of 28-day mortality. Both graphs visually point to the presence of heterogeneity in the effects of PMX-HA on 28-day survival in patients with sepsis. PMX-HA = Polymyxin B Hemadsorption