Table 2.
Univariate and multivariate COX analysis of characteristics extracted from SEER database
| Univariate COX analysis | Multivariate COX analysis | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OS | BCSS | OS | BCSS | |||||||||
| HR | 95%CI | P Value | HR | 95%CI | P Value | HR | 95%CI | P Value | HR | 95%CI | P Value | |
| Age at diagnosis | ||||||||||||
| < 40 | Reference | Reference | Reference | Reference | ||||||||
| 40–49 | 1.292 | 1.006–1.660 | * | 1.201 | 0.922–1.564 | 0.175 | 1.322 | 0.646–2.706 | 0.444 | 1.105 | 0.521–2.279 | 0.791 |
| 50–59 | 1.423 | 1.132–1.788 | ** | 1.371 | 1.080–1.740 | ** | 2.232 | 1.180–4.221 | * | 2.293 | 1.165–4.101 | * |
| 60–69 | 1.674 | 1.336–2.099 | *** | 1.608 | 1.270–2.037 | *** | 1.900 | 1.030–3.620 | * | 1.746 | 1.002–3.181 | * |
| 70–79 | 2.291 | 1.802–2.911 | *** | 2.175 | 1.692–2.796 | *** | 3.336 | 1.636–6.805 | *** | 3.737 | 1.845–7.569 | *** |
| 80 + | 2.710 | 2.056–3.574 | *** | 2.448 | 1.824–3.286 | *** | 1.908 | 0.764–4.767 | 0.166 | 2.282 | 1.061–5.617 | * |
| Months from diagnosis to therapy | ||||||||||||
| 0 month | Reference | Reference | Reference | Reference | ||||||||
| ≥ 1 month | 0.842 | 0.753–0.942 | ** | 0.846 | 0.751–0.953 | ** | 0.799 | 0.580–1.088 | 0.159 | 0.782 | 0.569–1.075 | 0.128 |
| Subtype | ||||||||||||
| HR + /HER2- | Reference | Reference | Reference | Reference | ||||||||
| HR + /HER2 + | 0.772 | 0.659–0.904 | ** | 0.790 | 0.668–0.934 | ** | 0.900 | 0.559–1.497 | 0.674 | 0.860 | 0.516–1.435 | 0.564 |
| HR-/HER2 + | 0.962 | 0.813–1.138 | 0.653 | 0.983 | 0.822–1.174 | 0.846 | 2.163 | 1.407–3.606 | *** | 2.029 | 1.251–3.290 | ** |
| HR-/HER2- | 1.744 | 1.511–2.015 | *** | 1.830 | 1.572–2.129 | *** | 3.575 | 2.380–5.771 | *** | 3.369 | 2.150–5.278 | *** |
| Race | ||||||||||||
| White | Reference | Reference | Reference | Reference | ||||||||
| Black | 1.266 | 1.107–1.448 | *** | 1.222 | 1.057–1.412 | ** | 1.002 | 0.601–1.496 | 0.994 | 0.936 | 0.581–1.510 | 0.787 |
| Other | 0.883 | 0.735–1.061 | 0.185 | 0.812 | 0.663–0.993 | * | 0.824 | 0.480–1.541 | 0.519 | 0.754 | 0.411–1.382 | 0.361 |
| Histological type | ||||||||||||
| IDC | Reference | Reference | Reference | Reference | ||||||||
| ILC | 0.992 | 0.779–1.262 | 0.947 | 0.955 | 0.738–1.236 | 0.728 | 2.794 | 1.266–6.197 | * | 2.838 | 1.297–6.214 | ** |
| Mixed | 0.887 | 0.679–1.158 | 0.449 | 0.857 | 0.644–1.139 | 0.287 | 1.040 | 0.536–2.027 | 0.908 | 0.934 | 0.468–1.862 | 0.846 |
| Other | 1.354 | 1.209–1.516 | *** | 1.225 | 1.083–1.386 | ** | 1.422 | 0.784–2.724 | 0.270 | 1.015 | 0.484–2.128 | 0.970 |
| Marital status | ||||||||||||
| Married | Reference | Reference | Reference | Reference | ||||||||
| Singled | 1.262 | 1.111–1.435 | *** | 1.251 | 1.091–1.435 | ** | 1.793 | 1.198–2.695 | ** | 1.879 | 1.253–2.819 | ** |
| Widow/divorced/other | 1.519 | 1.351–1.706 | *** | 1.531 | 1.353–1.734 | *** | 1.571 | 1.034–2.253 | * | 1.543 | 1.044–2.279 | * |
| T Stage | ||||||||||||
| T1 | Reference | Reference | Reference | Reference | ||||||||
| T2 | 1.064 | 0.878–1.291 | 0.526 | 1.146 | 0.931–1.412 | 0.199 | 1.839 | 0.986–3.360 | 0.051 | 1.915 | 0.998–3.650 | 0.056 |
| T3 | 1.137 | 0.921–1.405 | 0.233 | 1.231 | 0.981–1.545 | 0.073 | 1.652 | 0.784–3.289 | 0.168 | 1.543 | 0.756–3.146 | 0.233 |
| T4 | 1.248 | 1.042–1.495 | * | 1.337 | 1.099–1.626 | ** | 1.918 | 1.025–3.419 | * | 1.910 | 1.023–3.566 | * |
| N Stage | ||||||||||||
| N0 | Reference | Reference | refereNce | Reference | ||||||||
| N1 | 0.934 | 0.815–1.071 | 0.327 | 0.951 | 0.822–1.100 | 0.502 | 0.979 | 0.646–1.584 | 0.925 | / | / | / |
| N2 | 0.788 | 0.645–0.963 | * | 0.834 | 0.675–1.029 | 0.09 | 0.864 | 0.411–1.702 | 0.687 | / | / | / |
| N3 | 0.921 | 0.777–1.092 | 0.342 | 0.962 | 0.804–1.152 | 0.676 | 1.171 | 0.718–1.907 | 0.524 | / | / | / |
| Grade | ||||||||||||
| Well differentiated | Reference | Reference | Reference | Reference | ||||||||
| Moderately differentiated | 1.175 | 0.871–1.586 | 0.291 | 1.266 | 0.914–1.754 | 0.156 | 0.906 | 0.423–1.939 | 0.799 | 0.820 | 0.370–1.820 | 0.626 |
| Poorly differentiated | 1.435 | 1.072–1.921 | * | 1.561 | 1.137–2.145 | ** | 1.140 | 0.529–2.458 | 0.738 | 1.177 | 0.530–2.618 | 0.689 |
| Median household income(inflation adjusted) | ||||||||||||
| < 40,000$ | Reference | Reference | Reference | Reference | ||||||||
| 40,000–49,999$ | 1.055 | 0.823–1.352 | 0.676 | 1.006 | 0.774–1.308 | 0.965 | 0.559 | 0.254–1.230 | 0.148 | 0.604 | 0.277–1.320 | 0.207 |
| 50,000–59,999$ | 1.053 | 0.888–1.249 | 0.477 | 1.058 | 0.823–1.361 | 0.659 | 0.728 | 0.357–1.488 | 0.385 | 0.733 | 0.356–1.506 | 0.398 |
| 60,000–69,999$ | 0.931 | 0.805–1.076 | 0.748 | 0.936 | 0.742–1.181 | 0.579 | 0.724 | 0.381–1.377 | 0.325 | 0.651 | 0.341–1.243 | 0.193 |
| 70,000$ + | 0.760 | 0.656–0.879 | * | 0.751 | 0.595–0.948 | * | 0.522 | 0.271–1.006 | 0.052 | 0.523 | 0.273–0.999 | * |
| Chemotherapy | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.454 | 0.410–0.502 | *** | 0.477 | 0.428–0.531 | *** | 0.386 | 0.267–0.558 | *** | 0.436 | 0.301–0.637 | *** |
| Radiotherapy | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.629 | 0.568–0.697 | *** | 0.667 | 0.598–0.744 | *** | 0.721 | 0.499–1.042 | 0.082 | 0.753 | 0.520–1.092 | 0.135 |
| Surgery | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.619 | 0.529–0.724 | *** | 0.615 | 0.520–0.727 | *** | 0.693 | 0.430–1.117 | 0.132 | 0.742 | 0.464–1.186 | 0.212 |
| Bone metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.956 | 0.859–1.063 | 0.407 | 1.002 | 0.894–1.123 | 0.973 | / | / | / | / | / | / |
| Liver metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.290 | 1.159–1.436 | *** | 1.283 | 1.144–1.438 | *** | 1.286 | 0.892–1.860 | 0.179 | 1.264 | 0.877–1.823 | 0.209 |
| Lung metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.434 | 1.294–1.589 | *** | 1.426 | 1.278–1.592 | *** | 1.606 | 1.157–2.230 | ** | 1.698 | 1.219–2.365 | ** |
| Distant Lymph nodes metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.128 | 0.942–1.352 | 0.190 | 1.093 | 0.900–1.327 | 0.368 | / | / | / | / | / | / |
| Distant other metastases | ||||||||||||
| No/unknown | Reference | Reference | Reference | Reference | ||||||||
| Yes | 1.331 | 1.101–1.609 | ** | 1.322 | 1.079–1.620 | ** | 1.195 | 0.829–1.723 | 0.339 | 1.216 | 0.842–1.757 | 0.296 |
*P < 0.05,
**P < 0.01,
***P < 0.001