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. 2023 Apr 12;21(5):1117–1138. doi: 10.2174/1570159X20666220915092703

Fig. (2).

Fig. (2)

Graphical representation of consequences of mitochondrial dysfunction in ALS. Figure shows culprit genes of ALS and their associated pathways causing mitochondrial dysfunction. Other genes (tbk1, optn, sigma-1R) affect calcium homeostasis and mitophagy. SOD1 affects glucose metabolism, calcium homeostasis and mitophagy. FUS affects complex V assembly, mtDNA repair, mitochondrial motility/fragmentation, and calcium homeostasis. CHCHD10 affects cristae morphology and ETC function. TDP43 affects mitophagy, ETC complex translation and inflammation pathway. C9orf72 affects cristae morphology, ETC complex translation, complex I assembly and complex V degradation. Reproduced from ‘Metabolites’, Volume 12, authored by Niccolo Candelise, et al. Mechanistic Insights of Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis: An Update on a Lasting Relationship. Copyright © 2022 by the authors. Published by MDPI.; open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).