Table 2.

Radioligands used with the 6-OHDA PD model in the last 5 years.

Species Age	Model Induction Protocol	PET Timepoints	PET Tracer
Male C57/BL6J and TREM1-knockout mice 8-12 weeks old [116]	N/A Striatum (unilateral)	7 and 14 days post PD model induction	[18F]GE-180, [64Cu]TREM1-mAb, [64Cu]Isotype control-mAb
Male Long-Evans rats 3 months old [117]	21 μg / 3 μl MFB (unilateral)	1-7 months (every month) - tryptophan metabolism 4 days and 4 weeks - TSPO 1 and 4 weeks - dopaminergic system	7-[18F]fluorotryptophan ([18F]FTrp), [18F]FDOPA, [18F]DAA1106
Female Long-Evans WT rats 10-11 weeks old [118]	2x 6 μg / 3 μl MFB and SN (unilateral)	Day 21 - glucose metabolism Day 23 - SV2A	[18F]FDG, [11C]UCB-J
Male Wistar rats 9 weeks old [119]	21 μg / 5 μL Striatum (unilateral)	2 days after 6-OHDA and after LPS injection (same day)	[18F]FEPPA
Male Sprague-Dawley rats N/S [120]	4 μg / 2 μl (SN) and 10 μg / 2.5 μl (MFB)	10 weeks	[18F]FDOPA and [18F]FMT
Male Sprague-Dawley rats 1 year old [121]	8 μg or 16 μg / 4 μL (partial lesion and full lesion, respectively) MFB (unilateral)	Day 28	[18F]FP-(+)-DTBZ
C57Bl6 mice [122]	10 μg / 2 μl Striatum (unilateral)	2 weeks	[18F]IAM6067 - sigma 1 receptor - calcium signal modulator
Female Sprague-Dawley rats [96]	2 x 20µg / 4µL Striatum (unilateral)	9 weeks	[11C]UCB-J
Male Wistar rats adult [123]	3x – 4 µg / 2 µL Striatum (unilateral)	Day 14	[18F]LBT-999
Male Sprague-Dawley rats 8 weeks old [124]	20 μg / 4 μl Striatum (unilateral)	Days 7, 14 and 21	[18F]FTPQ
Female Wistar rats 8 weeks old [125]	24 μg / 4 μl Striatum (unilateral)	Day 4, 7, 14, 21, and 28	[11C]JNJ-717 and [18F]DPA-714#
Male Sprague Dawley rats 6 weeks old [126]	6 µg / 2.3 µl SN (bilateral)	3 weeks	[3H]SCH23390 - D1R, [125I]Iodosulpride - D2R and [125I]7OH-PIPAT - D3R#
C57/BL6J mice 11-15 weeks old [98]	10 μg / 2 μl SN (unilateral)	Days 7, 14 and 21	[18F]DPA-714
Male Long-Evans rats 3 months old [127]	21 μg / 3 μl MFB (unilateral)	Day 13-24 and Day 26-29	[18F]FDG and [18F]FDOPA