FIG 4.

Neutralizing titers against SARS-CoV-2 Gamma and Delta VOCs after Sputnik V vaccination. Neutralizing titers (NT) were defined as the highest serum dilution without any cytopathic effect on the monolayer using a replicating SARS-CoV-2 Gamma and Delta. Sera collected at 2 and 24 weeks after completion of the vaccination schedule (wpv) with Sputnik V were used. (A and B) Cohort was differentiated into the following individuals: (i) Non-COVID, black dots (n = 29); (ii) COVID-PreV, orange dots (n = 9); and (iii) COVID-PostV, purple dots (n = 9). Sera were evaluated against (A) SARS-CoV-2 Gamma and (B) Delta. Individual NT values and geometric mean with 95%CI are shown. Tables next to each graph indicate the corresponding GMNT, 95%CI values, and GMNT fold change of 24 versus 2 wpv. Pie charts illustrate the percentage of samples that resulted positive for neutralizing antibodies (NT ≥ 8). (C and D) NT at (C) 2 wpv or (D) 24 wpv of sera from 29 naive individuals. NT for each sample is shown, and lines connect the same sample. Pie charts illustrate the percentage of samples that resulted positive for neutralizing antibodies (NT ≥ 8). Samples with NT below 8 (limit of detection, LOD) were set at 1 to calculate GMNTs. Wilcoxon matched-pair test was used for longitudinal analysis of the neutralizing titer. For nonpaired samples analysis, the Mann-Whitney U test was used. Statistical significance is shown with the following notations: ****, P < 0.0001; *, P < 0.05; ns, not significant.