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. 2023 Jun 22;2023(6):CD001423. doi: 10.1002/14651858.CD001423.pub4

Reece Smith 1986.

Study characteristics
Methods Study design: parallel‐group randomized trial
Study dates: not available
Setting: inpatient, multicenter, national
Country: UK
Participants Inclusion criteria:
  • Difficulty in micturition

  • Impairment of urinary stream

  • Urinary urgency

  • Urinary hesitancy

  • Urinary intermittency

  • Terminal dribbling

  • A sensation of incomplete voiding

  • Average daytime micturitions

  • Average nocturnal micturitions

  • Libido


Exclusion criteria:
  • Malignant prostatic disease

  • Symptoms did not fulfill the entry criteria


Sample size: 70 randomized participants
Age (years):
Group 1 mean (SD): 66.15 (5.86)
Group 2 mean (SD): 67.03 (6.03)
IPSS score (baseline): not available
Prostate size: not available
Interventions Group 1 (n = 33): Permixon (2 capsules of 160 mg) once a day for 12 weeks. Contains fruits of Serenoa repens, a kind of palm tree
Group 2 (n = 37): placebo once a day for 12 weeks
Co‐interventions: none
Outcomes Adverse events
  • How measured: not described

  • Time points measured: possibly at 12 weeks follow‐up

  • Time points reported: possibly at 12 weeks follow‐up

  • Subgroups: none


Other outcomes measured in the trial: blood studies, urinary retention, and Qmax.
Notes Funding sources: not available
Declarations of interest: not available