Study	Reason for exclusion
Adriazola Semino 1992	Wrong study design/comparison: Serenoa repens vs active control (Prazosin). No indication of randomization
Al‐Shukri 2000	Wrong study design: non‐randomized study
Alcaraz 2022	Wrong study design: observational study
Ali 2020	Wrong comparison: Serenoa repens vs alpha‐blockers
Aliaev 2009	Wrong study population: men had chronic abacterial prostatitis
Authié 1987	Wrong study design: non‐randomized study
Bartsch 1998	Wrong comparison: Serenoa repens vs finasteride
Braeckman 1997	Wrong comparison: different doses of Serenoa repens
Cai 2013	Wrong comparison: IDIProst vs Serenoa repens
Carraro 1996	Wrong comparison: Serenoa repens vs finasteride
Comar 1986	Comparison with mepartricin
CTRI/2012/10/003049	Wrong comparison: different doses of phytotherapy
CTRI/2020/09/027521	Wrong comparison: Serenoa repens vs SAW‐1720
Debruyne 2002	Wrong comparison: with alpha‐blocker
Di Maida 2020	Wrong study design: non‐randomized comparative study
Di Silverio 1992	Tissue study investigating the antiestrogenic effect of Serenoa repens vs placebo
Duborija‐Kovacevic 2010	Wrong comparison: Serenoa repens vs doxazosin and finasteride
Engelmann 2006	Wrong comparison: Serenoa repens vs tamsulosin
EUCTR2011‐005307‐33‐FR	Wrong comparison: Serenoa repens vs tamsulosin
Gerber 1998	Wrong study design: no control group
Giannakopoulos 2002	Wrong study design: no control group
Giulianelli 2012	Wrong study design: observational study
Grasso 1995	Wrong comparison: Serenoa repens vs alpha‐blocker
Gurzhenko 2020	Wrong study design: observational study
Guzman 2016	Wrong comparison: D‐004 vs Serenoa repens
Hamdv 1997	Wrong comparison: Serenoa repens vs finasteride
Ju 2015	Wrong study design: no comparison
Latil 2015	Wrong comparison: Serenoa repens vs alpha‐blockers
Morgia 2013	Wrong study population: men subject to histologic sampling
Morgia 2018	Wrong comparison: Serenoa repens vs tadalafil
NCT00797394	Wrong comparison: Serenoa repens as a co‐intervention
Pannunzio 1986	Wrong comparison: Serenoa repens vs gestonorone caproate
Pavone 2010	Wrong study design: not a randomized controlled trial
Pecoraro 2004	Wrong population: study focused on the use of the drug as preoperative adjuvant treatment
Popa 2005	Wrong study design: independent re‐analysis of the included study Metzker 1996
Romaniuk 2013	Wrong comparison: Serenoa repens vs doxazosin and finasteride
Roveda 1994	Wrong comparison: Serenoa repens oral vs rectal route
Sinescu 2011	Wrong study design: non‐randomized study
Stepanov 1999	Wrong study design: no control group
Strauch 1994	Wrong comparison: Serenoa repens vs finasteride
Suardi 2014	Wrong patient population: men with prostatitis
Sökeland 1997	Wrong comparison: Serenoa repens vs finasteride
Taieb 2010	Wrong study design: observational study
Vela‐Navarrete 2005	Study focused on tissue samples of the prostate.
Veltri 2002	Wrong study population: study focused on prostatic tissue
Vinarov 2010	Wrong study design: no active or placebo control
Weisser 1997	Wrong study population: prostatic tissue (enzyme study)
Yamanishi 2004	Wrong comparison: Serenoa repens vs alpha‐blockers
Zlotta 2005	Wrong study design: re‐analysis of previous studies