Table 4. Attributable risk estimates with 95% CIs for an admission for myocarditis; exposures with elevated RIs with p < 0.001 0–6 days post-vaccine and 0 to 27 days post a laboratory confirmed SARS-CoV-2 in the SCCS analysis using the dataset that includes infections in unvaccinated individuals.
Vaccine exposure | Admissions in risk period | RI | Attributable fraction | Attributable cases | Doses | Attributable risk per million vaccinations (95% CI) |
---|---|---|---|---|---|---|
0 to 6 days before admission 16 to 39 year olds | ||||||
Dose 1 ChAdOx1 | 9 | 5.23 | 0.809 | 7.3 | 2,099,584 | 3.5 (2.6,3.9) |
Dose 1 BNT162b2 | 18 | 2.23 | 0.552 | 9.9 | 9,705,976 | 1.02 (0.5,1.3) |
Dose 2 BNT162b2 | 40 | 5.34 | 0.813 | 32.5 | 9,519,878 | 3.4 (3.1,3.6) |
Booster BNT 162b2 | 17 | 4.38 | 0.772 | 13.1 | 5,319,875 | 2.5 (2.0,2.8) |
Dose 1 mRNA 1273 | 8 | 8.69 | 0.885 | 7.1 | 1,023,825 | 6.9 (5.9,7.4) |
Dose 2 mRNA 1273 | 38 | 56.48 | 0.982 | 37.3 | 881,058 | 42.4 (41.9,42.7) |
Booster mRNA 1273 | 11 | 7.88 | 0.873 | 9.6 | 2,144,219 | 4.5 (3.9,4.8) |
Vaccine exposure | Admissions in risk period | RI | Attributable fraction | Attributable cases | Doses | Attributable risk per million vaccinations (95% CI) |
0 to 6 days before admission all 16+ year olds | ||||||
Dose 2 BNT162b2: males | 40 | 4.42 | 0.774 | 31.0 | 8,734,711 | 3.5 (3.1,3.8) |
Dose 1 mRNA 1273: males | 9 | 10.48 | 0.905 | 8.1 | 747,072 | 10.9 (9.6,11.5) |
Dose 2 mRNA 1273: males | 35 | 58.24 | 0.983 | 34.4 | 625,871 | 55.0 (54.3,55.3) |
Booster mRNA 1273: males | 12 | 3.8 | 0.737 | 8.8 | 3,539,697 | 2.5 (1.7,2.9) |
Dose 2 mRNA 1273: females | 4 | 23.26 | 0.957 | 3.8 | 498,121 | 7.7 (6.8,7.9) |
SARS-CoV-2 infection 0–27 days before admission | Admissions in risk period | RI | Attributable fraction | Attributable cases | Cases | Attributable risk per million infections |
16 to 39 year olds day 0 | 15 | 6.98 | 0.857 | 12.9 | 8,398,257 | 1.5 (1.4–1.6) |
≥40 year olds day 0 | 37 | 23.56 | 0.958 | 35.4 | 6,570,699 | 5.4 (5.6, 5.5) |
16–39 year olds days 1–27 | 113 | 2.09 | 0.522 | 58.9 | 8,398,257 | 7.0 (5.5, 8.3) |
≥40 year olds days 1–27 | 124 | 3.07 | 0.674 | 83.6 | 6,570,699 | 12.7 (11.3, 13.9) |
CI, confidence interval; RI, relative incidence; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2; SCCS, self-controlled case series.