Table 2.
Comparison of blood pressure, cardiovascular parameters between the two groups of PD patients at baseline and after 24 months of follow-up.
| Roxadustat (n = 60) | rHuEPO (n = 60) | |||||
|---|---|---|---|---|---|---|
| Baseline variable | After 24 months of follow-up | Change from baseline | Baseline | After 24 months of follow-up | Change from baseline | |
| Systolic blood pressure (mmHg) | 131.3 ± 15.9 | 130.0 ± 12.5 | −1.28 ± 13.4 | 131.1 ± 15.9 | 138.1 ± 14.0*# | 7.02 ± 15.1# |
| Diastolic blood pressure (mmHg) | 85.0 ± 10.2 | 83.1 ± 7.7 | −1.93 ± 9.0 | 83.8 ± 10.1 | 89.8 ± 9.4*# | 5.35 ± 10.8# |
| Nocturnal hypertension, n (%) | 8 (13.3) | 5 (8.3) | −3 (−5) | 7 (11.7) | 18 (30)*# | 11 (18.3)# |
| Urine volume (mL) | 1,100 (112–1457.5) | 1,075 (157.5, 1437.5) | −50 (−100, 0) | 1,100 (725–1337.5) | 800 (450, 1087.5)*# | −200 (−487, −50)# |
| Weight (kg) | 59.4 ± 9.9 | 57.8 ± 10.4 | −0.4 ± 4.4 | 60.2 ± 10.8 | 59.7 ± 11.9 | −0.0 ± 6.8 |
| NT-proBNP (pmol/L) | 170.2 (56.5, 475.8) | 114.3 (34.4, 300.5) | −5.4 (−167.2, 158.5) | 119.1 (60.1, 456.3) | 424.4 (155.5, 1350.5)*# | 95.3 (−17.2, 494.0)# |
| TnT (ng/mL) | 0.019 (0.014, 0.034) | 0.027 (0.021, 0.064) | 0.007 (−0.004, 0.019) | 0.021 (0.0125, 0.036) | 0.066 (0.047, 0.0995)*# | 0.048 (0.029, 0.072)# |
| TnI (ng/mL) | 0.03 (0.02, 0.03) | 0.0275 (0.015, 0.03) | 0.005 (0,0.015) | 0.035 (0.025, 0.04) | 0.05 (0.0395, 0.06)*# | 0.02 (0.01, 0.04)# |
| IVS (mm) | 9.94 ± 1.52 | 10.03 ± 1.75 | −0.09 ± 1.74 | 10.26 ± 1.92 | 10.52 ± 1.53 | 0.28 ± 1.82 |
| LVPW (mm) | 9.94 ± 1.23 | 10.06 ± 1.85 | −0.38 ± 1.40 | 9.78 ± 1.43 | 10.1 ± 1.42 | 0.26 ± 1.94 |
| LVEF (%) | 62.8 ± 4.5 | 63.2 ± 4.8 | 0.9 ± 6.7 | 63.8 ± 6.1 | 60.9 ± 4.7*# | −3.3 ± 7.1# |
| Cardiothoracic ratio | 0.48 ± 0.06 | 0.49 ± 0.04 | −0.02 ± 0.05 | 0.48 ± 0.05 | 0.51 ± 0.07* | 0.04 ± 0.06# |
NT-proBNP, N-terminal pro-brain natriuretic peptide; TnT, troponin T; TnI, troponin I; IVS, interventricular septal; LVPW, left ventricular posterior wall thickness; LVEF, left ventricular ejection fraction.
Compared with baseline, *p<0.05; Compared with roxadustat group, #p<0.05.