TABLE 2.
First-line regimens for LTBI
| Regimen | Dosing |
|---|---|
| Isoniazida | 5 mg/kg (maximum, 300 mg) orally for 9 mo |
| Rifampin | 10 mg/kg (maximum, 600 mg) orally for 4 mo |
| Isoniazida and Rifapentine | Isoniazid (orally once weekly for 3 mo; direct observation is preferred): 15 mg/kg, rounded up to the nearest 50 or 100 mg; 900 mg maximum Rifapentine (orally once weekly for 3 mo; direct observation is preferred): 10–14 kg: 300 mg 14.1–25.0 kg: 450 mg 25.1–32.0 kg: 600 mg 32.1–49.9 kg: 750 mg ≥50 kg: 900 mg maximum |
a
In conjunction with pyridoxine supplementation (25–50 mg daily) to prevent peripheral neuropathy.
Abbreviation: LTBI, latent tuberculosis infection.