TABLE 3.

First-line drugs for the treatment of active TB

Drug	Common adverse events	Drug interactions
Isoniazid PO	Hepatotoxicity Neurotoxicity Cytopenias	Corticosteroids Azole antifungals
Rifampin PO	Hepatotoxicity Cytopenias Red-orange body fluids Interstitial nephritis Rash	Calcineurin inhibitors mTOR inhibitors Mycophenolate Corticosteroids Azole antifungals Atovaquone
Rifabutin PO	Same as Rifampin Uveitis	Similar to Rifampin but less severe Clarithromycin
Rifapentine PO	Same as Rifampin Hypersensitivity reactions	Similar to Rifampin
Pyrazinamide PO	Hepatotoxicity Cytopenias Hyperuricemia Interstitial nephritis	Cyclosporine
Ethambutol	Hepatotoxicity Neurotoxicity Cytopenias	—

Abbreviation: mTOR, mammalian target of rapamycin; PO, per os; TB, tuberculosis.