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. 2023 Jun 5;29(6):1400–1411. doi: 10.1038/s41591-023-02399-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Duration of treatment by genotype. Clinical benefit is defined as a treatment duration of at least 16 weeks (without evidence of progression) and/or a RECIST 1.1 or tumor marker response. The gray dotted line indicates 16 weeks. b, Case report for a patient (n = 1) with gRAD51C LOF ovarian cancer who had complete disappearance of the TLs. c, Case report for a patient (n = 1) with a gATM LOF pancreatic cancer who had a late response to camonsertib. 69F, 69-year-old female; 77F, 77-year-old female; g, genomic; Plt., platinum.