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. 2023 May 29;29(6):1448–1455. doi: 10.1038/s41591-023-02358-9

Fig. 1. Parameters describing the kinetics of α-synuclein aggregation in the serum IP/RT-QuIC and ROC analysis of the diagnostic performance of serum IP/RT-QuIC for synucleinopathy.

Fig. 1

a, Comparison of the forming rates of each group. The violin plots match those represented in the kinetic curves. Violin plots show the range and average distribution. The symbols indicate outliers according to Tukey’s test. Statistical analysis was performed using two-sided one-way ANOVA with Tukeyʼs multiple comparisons test, resulting in a significance of P < 0.001 (***) and P < 0.0001 (****) between each group (CTRL versus PD, P < 0.0001; CTRL versus MSA, P < 0.0001; CTRL versus DLB, P = 0.0001; CTRL versus PSP, P = 0.9914; CTRL versus AD, P = 0.8547; CTRL versus RBD, P = 0.9300; PD versus MSA, P = 0.9971; PD versus DLB, P = 0.9277; MSA versus DLB, P = 0.8415; PSP versus AD, P = 0.6755; PSP versus RBD, P = 0.9660; AD versus RBD, P > 0.9999; PD, MSA and DLB versus PSP, AD and RBD, P < 0.0001). b–d, ROC curves for serum IP/RT-QuIC comparing the control group to PD (b), MSA (c) and DLB (d). NS, not significant.