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. 2023 May 29;29(6):1448–1455. doi: 10.1038/s41591-023-02358-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Schematic view of the main morphology of serum IP/RT-QuIC products derived from patients with LB diseases and MSA. Arrows indicate the measurement sites. b, Negative-stained TEM images of serum IP/RT-QuIC products derived from patients with PD, DLB and MSA. c, Violin plots show the range and average distribution. Statistical analysis was performed using one-way ANOVA followed by Tukey’s correction, resulting in significances of P < 0.0001 (****) among PD, DLB and MSA (PD versus MSA, P < 0.0001; PD versus DLB, P = 0.9514; MSA versus DLB, P < 0.0001). We measured the widths of 10 fibrils and took measurements at two sites for each fibril (PD (n = 50), MSA (n = 25), DLB (n = 9)). Scale bars, 100 nm. NS, not significant.