Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 29;29(6):1448–1455. doi: 10.1038/s41591-023-02358-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023, corrected publication 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 2 — (a-d) Negative-stained transmission electron microscopy images of α-synuclein fibrils derived from serum and CSF by IP/RT-QuIC and RT-QuIC, respectively. (a) PD (case 2) and (b) MSA (case 2). The arrows indicate the measurement sites of the width. Scale bars are 100 nm. The widths of the amplified α-synuclein fibrils are shown for all (c) PD (n = 6: case 1, p = 0.5590; case 2, p = 0.7981; case 3, p = 0.7238; case 4, p = 0.7915 ; case 5, p = 0.3705; case 6, p = 0.6793) and (d) MSA cases (n = 3: case 1, p = 0.5801; case 2, p = 0.6237). The data represent mean ± SEM. Statistical analysis was conducted using a two-tailed t-test. We measured the width of 10 fibrils at two sites for each fibril. CSF, cerebrospinal fluid; MSA, multiple system atrophy; NS, not significant; PD, Parkinson’s disease.