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. 2023 May 29;29(6):1448–1455. doi: 10.1038/s41591-023-02358-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — α-synuclein seeds derived from the serum of PD or MSA cases were injected into the mouse striatum. The total area of the NeuN-positive neurons was quantified chronologically for (a) Str (n = 3: PD, p = 0.2282; MSA-P, p = 0.1409; MSA-C, p = 0.2306), (b) CTX (n = 3: PD, p = 0.411; MSA-P, p = 0.1465; MSA-C, p = 0.1953), and (c) SN (n = 3: PD, p < 0.0001; MSA-P, p < 0.0001; MSA-C, p < 0.0001). The total area of the Gst-pi-positive oligodendrocytes was quantified chronologically for (d) CTX (n = 3: PD, p = 0.053; MSA-P, p = 0.017; MSA-C, p = 0.003). Horizontal axis: time after α-synuclein seed injection; vertical axis: total area of NeuN-positive neurons or GST-pi-positive oligodendrocytes (μm2) per unit area (mm2). Data are represented as mean area per region ± SEM, n = 5 mice per group. Statistical analysis was conducted using two-sided one-way analysis of variance, resulting in significances of p < 0.0001 (****), p < 0.01 (**) and p < 0.05 (*) among each group. CTX, cortex; MSA, multiple system atrophy; MSA-C, MSA cerebellar variant; MSA-P, MSA Parkinsonian variant; NS, not significant; PD, Parkinson’s disease; SN, substantia nigra; Str, striatum.