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. 2023 Jun 15;29(6):1520–1529. doi: 10.1038/s41591-023-02372-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Kaplan–Meier-estimated curves for the risk of right-sided dysplasia over time. Patients were classified as I2 (red) or non-I2 (I1 or U, black), according to their transcriptional cluster (n = 64 PSC, n = 127 IBD). The gray dashed line marks the 0.5 probability of the event (dysplasia diagnosis after colitis). For patients who were sampled at multiple time points, they were classified as I2 if at any point they had an I2 signature, otherwise they were classified as non-I2. Time (years) was calculated from the diagnosis of intestinal colitis to either the first incidence of right-sided colitis or the last colonoscopy recorded. Patients are subset according to diagnosis, that is, IBD (left) or PSC (right). b, Kaplan–Meier curves as in a, but showing the risk of non-right-sided dysplasia over time (n = 64 PSC, n = 127 IBD). Statistical outliers for time of follow-up were removed from the analysis before calculating the Kaplan–Meier estimates and P value. Individuals are subset according to diagnosis, that is, IBD (left) or PSC (right). Censored points (no dysplasia diagnosed) are marked as +.