Table 2.
Summary of number of diseases associated with alcohol consumption by ICD-10 chapter, in men
| Ever-regular versus occasional drinking | Dose–response associations among current drinkers | Totala | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ICD-10 chapter | No. of diseases | Total no. of events | No. of events in current drinkers | Positive | Negative | Positive | Negative | Positive | Negative |
| I Infectious and parasitic | 7 | 8,010 | 2,501 | 1 | 0 | 1 | 0 | 1 | 0 |
| II Neoplasms | 27 | 26,064 | 9,437 | 9 | 0 | 5 | 0 | 10 | 0 |
| III Blood and immune-related | 3 | 1,596 | 527 | 0 | 0 | 2 | 0 | 2 | 0 |
| IV Endocrine, nutritional and metabolic | 6 | 15,645 | 5,227 | 1 | 1 | 2 | 0 | 2 | 1 |
| V Psychiatric and behavioral | 3 | 1,683 | 587 | 0 | 0 | 1 | 0 | 1 | 0 |
| VI Nerve-related | 7 | 7,649 | 2,574 | 2 | 0 | 1 | 0 | 2 | 0 |
| VII Eye and adnexa | 7 | 10,142 | 3,240 | 0 | 0 | 1 | 0 | 1 | 0 |
| VIII Ear and mastoid process | 3 | 2,131 | 667 | 0 | 0 | 0 | 0 | 0 | 0 |
| IX Circulatory | 26 | 101,913 | 30,784 | 9 | 0 | 10 | 0 | 14 | 0 |
| X Respiratory | 23 | 42,993 | 13,233 | 3 | 0 | 1 | 0 | 3 | 0 |
| XI Digestive | 29 | 39,118 | 13,624 | 6 | 0 | 6 | 1 | 9 | 1 |
| XII Skin and subcutaneous tissue | 4 | 2,241 | 789 | 0 | 0 | 1 | 0 | 1 | 0 |
| XIII Musculoskeletal | 15 | 21,240 | 6,892 | 3 | 0 | 2 | 0 | 3 | 0 |
| XIV Genitourinary | 15 | 18,422 | 5,419 | 0 | 0 | 0 | 1 | 0 | 1 |
| XVIII Other symptoms, signs and abnormal findings | 16 | 19,881 | 7,191 | 2 | 0 | 4 | 0 | 4 | 0 |
| XIX Injury, poisoning and other external causes | 12 | 12,509 | 4,402 | 3 | 0 | 1 | 0 | 4 | 0 |
| XX External causes | 4 | 2,304 | 763 | 3 | 0 | 4 | 0 | 4 | 0 |
| Total | 207 | 333,541 | 107,857 | 42b | 1 | 42c | 2 | 61d | 3 |
aIncluded disease associations from Cox regression analyses either significant (P < 0.05 for diseases classified as alcohol-related by the WHO, FDR-adjusted P < 0.05 for other diseases; two-sided) from the comparison of ever-regular versus occasional drinking or dose–response association analyses within current drinkers.
bOf the 42 diseases showing significant positive associations with ever-regular versus occasional drinking, 23 diseases were classified as alcohol-related by the WHO.
cOf the 42 diseases showing significant positive dose–response associations among current drinkers, 22 diseases were classified as alcohol-related by the WHO.
dOf the 61 diseases showing significant positive associations with alcohol, 28 diseases were classified as alcohol-related by the WHO (of which 25 diseases passed FDR significance at FDR-adjusted P < 0.05 and 3 diseases were nominally significant at P < 0.05).