Table 1. Studies included in the review.

ETA: endoscopic transcecal appendectomy

References	Results	Clinical implications
Guo et al. (2022) [6]	In all 13 cases that were the focus, technical success relative to complete resection was documented. With no tumor recurrence and also a period of eight days affirmed to be the median length of hospital stay following ETA implementation, it was concluded that ETA exists as an effective, safe, and feasible procedure for appendiceal orifice lesions’ complete resection.	The study increased the understanding of the need for additional larger multicenter prospective studies aimed at ascertaining the efficacy of the ETA procedure.
Liu et al. (2019) [7]	During and after the ETA procedure, no significant adverse events such as bleeding were reported even after 10 months of follow-up.	ETA exists as a safe procedure, pointing to the need to consider implementing it in future clinical contexts following the identification of eligible candidates.
Muramoto et al. (2021) [8]	Under laparoscopic single-port assistance, ETA was confirmed to be a less invasive procedure compared to conventional laparoscopic resection. Additionally, it was avowed that ETA can be implemented more efficiently and safely compared to situations where endoscopy is implemented alone.	The study formed a baseline and proved foundational in informing the need for future studies to center on the accumulation of additional data relative to the outcomes of the ETA treatment, as well as the importance of considering how to perform ETA safely in eligible patients.
Yuan et al. (2019) [9]	Through a colonoscopic approach, ETA was found to be a promising and successful approach to transcecal appendectomy, with findings suggesting that given that the technique does not come with a skin incision, the option is marked by safety, and so, it is a promising and good alternative for appendiceal disease treatment.	The results were highly contributory to the current state-of-the-art, prompting the need for future clinical studies to examine these beneficial effects with which ETA continues to be associated but focusing on long-term follow-up and larger samples, hence assessing and validating the safety of the intervention.
Atallah et al. (2018) [10]	In this study, ETA was performed successfully, and its feasibility was ascertained relative to its evolution as an alternative technique for addressing and mitigating the problem of the appendiceal orifice.	The findings provided room for future studies to focus on different research populations and also research contexts to inform the sustainability of ETA, as well as shed more light on the technique’s safety when applied to different patient groups in different environments and also with varying degrees of disease severity.