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. 2023 Jun 22;6:660. doi: 10.1038/s42003-023-05045-0

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© The Author(s) 2023, corrected publication 2023

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Fig. 1 — a Top ten downregulated pathways upon AXL inhibition. Pathways associated with the downregulation of the cell cycle, mitosis and DNA replication are highlighted in red. b Proliferation curve of SKOV3 treated with R428 compared to DMSO. Cell viability was normalised against mean viability at day 0 assessed with CellTiter-Glo. c Representative flow cytometry plot of cell cycle analysis in SKOV3 treated with R428 for 24 h compared to DMSO. Ten thousand events were recorded for each sample. d Quantification of cell cycle analysis of SKOV3 treated with R428 for 16 h and 24 h showing the percentage of cells in different phases of the cell cycle (G₁, S, G₂/M [G₂ and mitosis]). Data represent mean ± s.e.m.; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, determined by Dunnett’s multiple comparisons tests.