Skip to main content
. 2023 Jun 22;6:660. doi: 10.1038/s42003-023-05045-0

Fig. 3. AXL inhibition sensitises cells to ATR inhibition.

Fig. 3

Combination treatment of R428 with BAY1895344 in a SKOV3, b HeyA8, c RMG5 and d PEO1. e Combination index of R428 and BAY1895344. f Dose reduction index of BAY1895344; Fa fraction affected. g Fluorescence intensity quantification of γH2AX in SKOV3 and h RMG5 treated with combination treatment of AXL and ATR inhibition. Data represent mean ± s.e.m.; *p < 0.05, **p < 0.01, ***p < 0.001, determined by two-tailed t-test with statistical significance with Welch’s correction. i Relative tumour volume change against the baseline. Data represent mean ± s.e.m.; *p < 0.05, **p < 0.01, ***p < 0.001, determined by two-tailed t-test with statistical significance with Welch’s correction; n = 14 tumours treated with DMSO, n = 11 tumours treated with R428, n = 11 tumours treated with BAY1895344, and n = 13 treated with combination treatment.