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. 2023 Jun 22;14:3737. doi: 10.1038/s41467-023-39444-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Refined cryo-EM map of the TGR-9 complex at 3.6 Å and its superposition with the resulting PDB model. The additional density ascribed to compound 9 and to the FAD are shown as pink and green continued surfaces, respectively. b Magnification of the doorstop pocket with 9 in two orientations (conformation 1 in magenta sticks; conformation 2 in pink sticks); the subpockets A-C are indicated as well as FAD shown as green sticks. c Interactions of the two conformers of compound 9 with surrounding amino acids.